An injection of an anti-inflammatory agent is often given to relieve pain in a joint area. The injection helps to reduce inflammation and swelling. It will help to maintain movement and function at the site. The injection of anti-inflammatory medication, often combined with a local anesthetic, can be given into the joint (intraarticular) or into the area around the joint (periarticular). The local anesthetic provides an immediate decrease in pain sensation and can last up to a few hours. It may take 3 to 5 days to feel the effects of the anti-inflammatory medication. These effects usually last 3 to 4 weeks or longer. Periarticular and Intra articular Joint Injections are most commonly given to treat arthritis, injury, tendonitis, and bursitis (inflammation in the area around a joint).